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Anti-TIA1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1406530
规格纯度
purified immunoglobulin, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-TIA1 antibody produced in mouse
产品介绍:

产品说明

一般描述

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. (provided by RefSeq)
T cell-restricted intracellular antigen-1 (TIA1) is encoded by the gene mapped to human chromosome 2p13.3. Alternative splicing of TIA1 leads to the formation of two isoforms such as, TIA1a and TIA1b. It is expressed in variety of tissues, including carcinoma, adenocarcinoma, wilms tumor, kidney, leukapheresis, thymus, whole embryo, malignant melanoma, uterus and hypothalamus.

免疫原

TIA1 (AAH15944.1, 1 a.a. ~ 214 a.a) full-length human protein.

Sequence
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYECRCIGEEKEMWNFGEKYARF

生化/生理作用

T cell-restricted intracellular antigen-1 (TIA1) plays a vital role in regulation of mRNA metabolism. It acts as a suppressor of mRNA decay of SKP2 (S-phase kinase-associated protein 2). It also induces translation of CCNA2 (cyclin A2) mRNAs. Variations in the gene expression leads to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In addition, mutation in the gene is also associated with the pathogenesis of Welander distal myopathy (WDM).

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~24.1 kDa
species reactivityhuman
technique(s)western blot: 1 μg/mL
NCBI登记号BC015944
UniProt登记号P31483
运输dry ice
储存温度−20℃
Gene Informationhuman ... TIA1(7072)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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