产品说明
一般描述
Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.
免疫原
Synthetic peptide from human TICAM1 / TRIF.
生化/生理作用
Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: suitable |
| UniProt登记号 | Q8IUC6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TICAM1(148022) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
