产品说明
一般描述
Transmembrane protein 106A (TMEM106A) is a type II transmembrane protein localized in mitochondria and plasma membrane. In human chromosome, the gene TMEM106A is localized at 17q21.31.
免疫原
Antibody was raised against a 14 amino acid peptide near the amino terminus of human TMEM106A.
生化/生理作用
In gastric cancer cells, transmembrane protein 106A (TMEM106A) is methylated and downregulated. Expression of TMEM106A leads to suppression of cell growth and leads to apoptosis of gastric cancer cells. Expression of TMEM106A in renal cancer suppresses cell growth, cell migration and induces caspase 3 dependent apoptosis. TMEM106A is expressed in all neural cell lines. The mRNA levels of TMEM106A is upregulated in Alzheimer′s disease (AD) brain when compared to non-AD brain.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500658.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 分子量 | 29 kDa |
| species reactivity | mouse, human |
| 浓度 | 1 mg/mL |
| technique(s) | ELISA: suitable western blot: suitable |
| NCBI登记号 | NP_659478 |
| UniProt登记号 | Q96A25 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TMEM106A(113277) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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