Anti-TMPRSS3, C-Terminal antibody produced in rabbit

产品说明

一般描述

Anti-TMPRSS3 Antibody detects endogenous levels of total TMPRSS3 protein.
The TMPRSS3 (transmembrane protease, serine 3) gene is mapped to human chromosome 21q22.3. It encodes for a transmembrane protein that is expressed in stria vascularis of the cochlear duct, spiral ganglion neurons, and hair cells. The structure of serine protease includes a transmembrane domain, a scavenger receptor cysteine rich domain (SRCR), a domain for low density lipoprotein receptor A , and a serine protease domain at its carboxyl terminal.

免疫原

The antiserum was produced against synthesized peptide derived from human TMPRSS3.

Immunogen Range: 405-454

生化/生理作用

The TMPRSS3 (transmembrane protease, serine 3) protein promotes the perilymph and endolymph development and also maintains it in the inner ear. TMPRSS3 is associated with cancer progression. Upregulation of the TMPRSS3 is observed in breast pancreatic, colorectal and ovarian cancer and might serve as an important biomarker for the same. Mutation in this gene causes autosomal recessive nonsyndromic hearing impairment.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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