Anti-TRIM68 antibody produced in rabbit

产品说明

一般描述

The gene TRIM68 (tripartite motif containing 68) belongs to the tripartite motif-containing protein (TRIM) family, the members of which contain a RING (really interesting new gene) finger, a B-box and a coiled-coil motif. Additionally, trim68 contains a carboxy-terminal PRY/SPRY (splA kinase and ryanodine receptors) domain. The gene is mapped to human chromosome 11p15.4.

免疫原

Tripartite motif-containing protein 68 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

The members of TRIM (tripartite motif-containing protein) family of proteins participate in several biological processes. Alteration in their expression is associated with genetic diseases, viral infection, and cancer development. TRIM68 (tripartite motif containing 68) interacts with androgen receptor (AR) and serves as its co-activator. It possesses ubiquitin ligase activity and may function in AR-dependent transcription. It has been found to be associated with Sjögren′s syndrome and serves as a diagnostic marker. Trim68 is highly expressed in prostate and may be involved in carcinogenesis.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST76051.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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