产品说明
一般描述
TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.
免疫原
Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.
生化/生理作用
TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500666.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 分子量 | 49 kDa |
| species reactivity | mouse, human |
| 浓度 | 1 mg/mL |
| technique(s) | ELISA: suitable immunocytochemistry: suitable western blot: suitable |
| UniProt登记号 | Q53H54 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TRMT12(55039) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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