Anti-UBXN1 antibody produced in rabbit

产品说明

一般描述

UBX domain-containing protein 1 (UBXN1) contains a ubiquitin-associated (UBA) motif and a ubiquitin regulatory X (UBX) domain.

免疫原

UBX domain-containing protein 1 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

UBX domain-containing protein 1 (UBXN1) recognizes breast cancer 1 (BRCA1) which is autoubiquitinated. This takes place by the binding of the ubiquitin-associated (UBA) domain of UBXN1 to the K6-linked polyubiquitin chains linked to BRCA1. The C-terminal sequences of UBXN1 also bind to the BRCA1/ BRCA1 associated RING domain 1 (BARD1) heterodimer. It then reduces the E3 ligase activity of BRCA1/BARD1 which is dependent on the ubiquitination status of BRCA1. It also functions as a negative regulator of tumor necrosis factor α (TNFα)-mediated nuclear factor kappa B (NF-κB) activation. UBXN1 interacts with the cellular inhibitors of apoptosis proteins (cIAPs) and with E3 ubiquitin ligases, which are a part of receptor-interacting protein 1 (RIP1) in the TNFα receptor complex. It tightly binds to cIAP1, blocks its recruitment to TNFR1 and inhibits the RIP1 polyubiquitination in response to TNFα.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST70262.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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