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Anti-VAC14 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200075
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
5001.78 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-VAC14 (C-terminal) antibody produced in rabbit
Anti-TAX1BP2
Anti-TRX
Anti-TAX1BP2 TAX-reactive protein x
Anti-ArPIKfyve
Anti-TAX1-binding protein 2
产品介绍:

产品说明

一般描述

VAC14 gene is mapped to human chromosome 16q22.1-q22.2. VAC14 is a scaffold protein and is a component of the PIKfyve protein kinase complex.

特异性

Anti-VAC14 (C-terminal) specifically recognizes human, mouse, and rat VAC14.

应用

Anti-VAC14 (C-terminal) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

VAC14 phosphorylates PtdIns(3)P to generate the housekeeping phospholipid PtdIns(3,5)P2. It associates with and upregulate PIKfyve phosphoinositide-5-kinase activity. VAC14-PIP5K3- PtdIns(3,5)P2 pathway is thought to be physiologically linked to insulin activation of glucose transport into the cell. Knockout of the VAC14 gene in mice results in massive neurodegeneration and particularly affected are neurons in the midbrain and of the peripheral sensory system.
VAC14 is a regulator of PIP5K3/PIKfyve, a dual specificity kinase.
Mutation in VAC14 gene leads to the development of retinitis pigmentosa (RP).

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~82 kDa
species reactivityrat, mouse, human
包装antibody small pack of 25 μL
浓度~1.5 mg/mL
technique(s)immunoprecipitation (IP): 10-15 μg using A431 cell lysates
indirect immunofluorescence: 8-16 μg/mL using HeLa cells
western blot: 1-2 μg/mL using extracts of mouse brain (S1 fraction) or rat brain (S1 fraction)
UniProt登记号Q08AM6
运输dry ice
储存温度−20℃
Gene Informationhuman ... VAC14(55697)
rat ... Vac14(307842)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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