Anti-VAPB antibody produced in rabbit

产品说明

一般描述

Vesicle-associated membrane protein-associated protein (VAPB) is encoded by the gene mapped to human chromosome 20q13.32. The encoded protein is characterized with a major sperm protein (MSP) domain and amphipathic helical structure, which might form coiled/coil protein-protein interaction motif and a hydrophobic C- terminus. VAPB is ubiquitously expressed and is localized to the intracellular membranes, such as endoplasmic reticulum (ER) and the Golgi apparatus.
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. (provided by RefSeq)

免疫原

VAPB (AAH01712, 1 a.a. ~ 243 a.a) full-length human protein.

Sequence
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL

生化/生理作用

Vesicle-associated membrane protein-associated protein (VAPB) facilitates endoplasmic reticulum (ER)-Golgi transport and secretion. In addition, it is also involved in various processes, such as ER stress and the unfolded protein response (UPR) and bouton formation at the neuromuscular junction. VAPB acts along with protein tyrosine phosphatase-interacting protein 51 (PTPIP51) to regulate calcium homeostasis. Mutation in the gene is associated with development of various disorders, such as amyotrophic lateral sclerosis 8 (ALS8), late-onset spinal muscular atrophy finkel type.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

产品性质

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