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Anti-VHL (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200285
包装型号
规格纯度
~1.5 mg/mL
参考价格
4435.79 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-VHL (C-terminal) antibody produced in rabbit
Anti-VHL1
Anti-HRCA1
Anti-RCA1
Anti-von Hippel-Lindau tumor suppressor
产品介绍:

产品说明

一般描述

Von Hippel-Lindau (VHL) gene encodes a 213 amino acid polypeptide. VHL interacts stably with proteins like Fibronectin, Elongin B and Elongin C, Cullin-2 and Rbx1. pVHL is shuttled from nucleus to cytoplasm depending on the transcription manner. VHL tumor suppressor gene is located on human chromosome 3p25.3. VHL disease is an autosomal dominant disorder.

免疫原

synthetic peptide corresponding to a sequence located at the C-terminus of human VHL, conjugated to KLH. The corresponding sequence is identical in human VHL isoform 2.

生化/生理作用

Von Hippel-Lindau (VHL) is known to regulate cellular metabolism by modulating hypoxia-inducible factor (HIF-1) proteins. VHL protein (pVHL) is used as a marker for proliferative lesions. VHL disease is a hereditary cancer syndrome, which is characterized by vascular tumors. It is caused by the inactivation of VHL protein. Expression of VHL gene is deregulated in papillary thyroid cancers (PTC). Mutations in this gene causes sporadic clear cell renal carcinomas as well as von Hippel-Lindau disease, which is characterised by hemangioblastoma.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~27 kDa
species reactivityhuman
浓度~1.5 mg/mL
technique(s)immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded human kidney.
indirect immunofluorescence: 5-10 μg/mL using HeLa cells.
western blot: 1-2 μg/mL using HEK-293T cells overexpressing human VHL.
UniProt登记号P40337
运输dry ice
储存温度−20℃
Gene Informationhuman ... VHL(7428)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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