Anti-VPS9D1 antibody produced in rabbit

产品说明

免疫原

Uncharacterized protein C16orf7 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

VPS9D1 (Vacuolar Protein Sorting 9 Domain-containing gene 1) gene encodes a protein containing VPS9 domain with ATP synthase and GTPase activator activity. The VPS9 domain is highly conserved and is involved in the activation of Rab5 GTPase, which mediates cell signaling via endocytosis of intracellular receptors. It also associates with GRB2 (growth factor receptor-bound factor 2), an adaptor protein that binds SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) in response to growth factors, and activates membrane-bound Ras, resulting in increased cell proliferation and survival. GRB2 is also involved in calcium-regulated signaling in B-cells. Together, the increased expression of VPS9D1 and its missense variants along with upregulation of GRB2 that is observed in survivors of sepsis, results in enhanced cellular proliferation and survival, activation of B- and T-cells, and proapoptotic activity.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST70858.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

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