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Anti-WNT5A antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1411396
规格纯度
purified immunoglobulin, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-WNT5A antibody produced in rabbit
hWNT5A
产品介绍:

产品说明

一般描述

Wnt family member 5A (WNT5A) is a secreted, proinflammatory protein. It belongs to the noncanonical WNT family. The gene encoding this protein is mapped to human chromosome 3p14.3.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction. (provided by RefSeq)

免疫原

WNT5A (NP_003383.2, 1 a.a. ~ 380 a.a) full-length human protein.

Sequence
MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK

生化/生理作用

Wnt family member 5A (WNT5A) has a role in metabolic dysfunction in obesity and negatively modulates angiogenesis in adipose tissue. The protein regulates cell motility and polarity by activating β-catenin–independent pathways. It has been shown to be overexpressed in gliomas. In addition, elevated expression of Wnt5a also contributes to the development of human melanoma cells. Thus, Wnt5a pathway is suggested to be a potential target for the treatment of melanoma.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 42.3 kDa
species reactivityhuman
technique(s)proximity ligation assay: suitable
western blot: 1 μg/mL
NCBI登记号NM_003392
UniProt登记号P41221
运输dry ice
储存温度−20℃
Gene Informationhuman ... WNT5A(7474)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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