产品说明
一般描述
Anti-YAP Antibody detects endogenous levels of total YAP protein.
Yes associated protein (YAP) is a 65kDa proline-rich phosphoprotein. It is encoded by the gene mapped to human chromosome 11q22.1. The encoded protein is characterized with a WW domain, a PDZ interaction motif, an SH3 binding motif and a coiled-coil domain.
免疫原
The antiserum was produced against synthesized peptide derived from human YAP.
Immunogen Range: 93-142
生化/生理作用
Yes associated protein (YAP) serves as a potent mechanosensitive transcriptional activator. It plays a vital role in regulation of cancer, regeneration and organ size. Overexpression of the gene contributes to tumorigenesis in breast and liver cancers. In addition, it also promotes gallbladder cancer (GBC) cell growth via activating AXL receptor tyrosine kinase/mitogen-activated protein kinase (MAPK) pathway. Thus, it acts as a potent biomarker and therapeutic target for various cancers including, GBC and breast cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD04118707 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 48 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 western blot: 1:500-1:1000 |
| NCBI登记号 | P46937 |
| UniProt登记号 | P46937 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... YAP1(10413) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
