产品说明
一般描述
Zinc transporter ZIP6, also known as Estrogen-regulated protein LIV-1 or Solute carrier family 39 member 6 orZrt- and Irt-like protein 6 (ZIP-6), and encoded by the gene name ZIP6 or SLC39A6 or LIV1 is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP-6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP-6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP-6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP-6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.
特异性
This antibody is recognizes isoforms at ~48 and ~85 kDa and is predicted to not cross-react with other ZIP family members.
免疫原
Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human Anti-ZIP-6.
应用
Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected Anti-ZIP-6 in mouse lung tissue.
Research Category
Apoptosis & Cancer
Anti-ZIP-6 Antibody detects level of ZIP-6 & has been published & validated for use in ZIP-6.
质量
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected Anti-ZIP-6 in mouse lung tissue lysate.
目标描述
~48 and ~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 2 isoforms produced by alternative splicing at ~49 kDa and ~85 kDa
外形
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | mouse |
technique(s) | immunohistochemistry: suitable western blot: suitable |
UniProt登记号 | Q13433 |
运输 | wet ice |
Gene Information | human ... SLC39A6(25800) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich