5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮

产品名称：

520-36-5
Apigenin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
4′,5,7-Trihydroxyflavone
芹菜素
4 ′,5,7-三羟基黄酮
5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮

产品介绍：

产品说明

一般描述

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

应用

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

生化/生理作用

一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
PubChem化学物质编号	329747355
NACRES	NA.24

产品性质

等级	primary reference standard
保质期	limited shelf life, expiry date on the label
manufacturer/tradename	HWI
mp	>300 ℃ (lit.)
application(s)	food and beverages
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3