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位置:首页 > 品牌 > Sigma-Aldrich > β-N-Acetylglucosaminidase Assay Kit

β-N-Acetylglucosaminidase Assay Kit

品牌
Sigma-Aldrich
货号
MAK456
规格纯度
Sufficient for 100 colorimetric tests
参考价格
5184.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
β-N-Acetylglucosaminidase Assay Kit
产品介绍:

产品说明

一般描述

β-N-Acetylglucosaminidase (NAG) is a lysosomal enzyme involved in a variety of biological processes such as the degradation of glycoproteins and glycolipids, cell proliferation, and signal transduction. NAG is found in many tissues in the body, but due to its high molecular weight, it cannot be filtered through the glomerular membrane. For this reason, in the presence of tubular damage or a glomerular lesion, urinary NAG activity increases. Elevated NAG levels in urine are an early indication of renal damage, such as injury due to diabetes mellitus, inflammation, nephritic syndrome, urinary tract infection, and more. Various forms of cancer have been associated with increased levels of NAG in serum. Genetically inherited lipid storage disorders, such as Tay-Sachs and Sandhoff disease, arise from deficiencies of the enzyme.

特点和优势

  • Linear detection range (20 μL sample): 0.2 to 50 U/L for a 30 minute reaction at 37 ℃.
  • Compatible with high-throughput handling systems.

适用性

The kit is suitable for β-N Acetylglucosaminidase activity determination in urine, serum, plasma, cell lysate, etc.

原理

The β-N-Acetylglucosaminidase Assay Kit is based on the cleavage of p-nitrophenol from a synthetic substrate. p-Nitrophenol becomes intensely colored after addition of the stop reagent. The increase in absorbance at A405 nm after addition of the stop reagent is directly proportional to the enzyme activity.

产品性质

质量水平100
detection methodcolorimetric
相关疾病endocrinological disorders, diabetes; genitourinary disorders
储存温度−20℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P264 - P280 - P305 + P351 + P338 - P337 + P313
危险分类Eye Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 1

Sigma-Aldrich

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