BMS-378806

产品名称：

357263-13-9
BMS-378806
BMS 806
4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R)-methylpiperazine
BMS-806
BMS378806
1-[(2R )-4-Benzoyl-2-methyl-1-piperazinyl]-2-(4-methoxy-1H -pyrrolo[2,3-b ]pyridin-3-yl)-1,2-ethanedione
BMS806
BMS 378806

产品介绍：

产品说明

生化/生理作用

BMS-378806 (BMS-806) is a potent and selective HIV-1 attachment inhibitor that blocks HIV glycoprotein 120 (gp120) from interacting with host T-cell surface glycoprotein CD4 (IC50 = 100 nM against CD4 for binding gp120; CYP1A2/2C9/2C19/2D6/3A4 IC50 >23 μM) without affecting HIV integrase, protease, or reverse transcriptase activity. BMS-806 effectively prevents various HIV-1 isolates from replication (EC50 from 0.85 to 26.5 nM in MT-2 and PM1 cultures; host cytotoxicity IC50 >300 μM) without affecting HIV-2, SIV, MuLV, RSV, HCMV, BVDV, VSV, or influenza virus.

基本信息

经验(实验)分子式	C₂₂H₂₂N₄O₄
分子量	406.43

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to gray
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable