产品说明
一般描述
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Bromodomain and PHD finger containing 3 (BRPF3) is a component of the MOZ/MORF histone acetyltransferase (HAT) complex. The addition of BRPF proteins to MOZ/MORF increases its HAT activity.3 Consequently, BRPF3 is likely to play a role in regulation of transcriptional activation by MOZ/MORF. This product contains the first bromodomain of BRPF3.
外形
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 41.2 kDa (576-701 aa + NT GST Tag) |
| 包装 | pkg of 100 μg pkg of 20 μg |
| UniProt登记号 | Q9ULD4 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... BRPF3(27154) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 - H319 - H412 |
| 预防措施声明 | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
| 危险分类 | Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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