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CD152 (human): FC (human) (non-lytic)

CD152(人):FC(人)(非分解)

品牌
Sigma-Aldrich
货号
SRP8051
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
参考价格
1734.44 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
CD152 (human): FC (human) (non-lytic)
CTLA-4
Hepatitis A virus cellular receptor 2
Cytotoxic T-lymphocyte-associated antigen 4
CD152(人):FC(人)(非分解)
产品介绍:

产品说明

一般描述

CD152 (CTLA-4 (cytotoxic T-lymphocyte associated protein 4)) and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain.
CD152 and CD28 are both expressed on the cell surface as homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

生化/生理作用

CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2 (cluster of differentiation 80 and 86 respectively), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CTLA-4 (cytotoxic T-lymphocyte associated protein 4) is known to prevent immune responses, and its deficiency causes fatal lymphoproliferation in mouse models. Overexpression of the gene is observed in rheumatoid arthritis. Mutation in CTLA-4 is associated with insulin-dependent (type 1) diabetes mellitus, Grave′s disease and Hashimoto′s thyroiditis.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute at 100 μg/mL in sterile PBS.

其他说明

The extracellular domain of human CD152 [CTLA-4] (aa 37-160) is fused to the N-terminus of the Fc region of a mutant human IgG1.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in CHO cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量monomer 39 kDa by calculation
包装pkg of 100 μg
杂质<0.06 EU/μg endotoxin, tested
颜色 white
UniProt登记号P16410
运输wet ice
储存温度−20℃
Gene Informationhuman ... CTLA4(1493)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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