产品说明
一般描述
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
外形
Lyophilized from 0.2 μm-filtered solution in PBS.
重悬
Reconstitute at 100 μg/mL in sterile PBS.
其他说明
The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in CHO cells |
| 测定 | ≥98% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | monomer 46 kDa by calculation |
| 包装 | pkg of 100 μg |
| 杂质 | <0.06 EU/μg endotoxin, tested |
| UniProt登记号 | Q15116 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PDCD1(5133) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
