产品说明
一般描述
CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli.
生化/生理作用
CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5+ cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).
外形
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥80% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 41 kDa (371 aa, 25-372 aa + His tag) |
| 包装 | pkg of 50 μg |
| 浓度 | 1 mg/mL |
| 杂质 | <1 EU/μg endotoxin (LAL test) |
| UniProt登记号 | P06127 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... CD5(921) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
