产品说明
一般描述
Casein kinase 1 δ (CK1δ) is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair.
生化/生理作用
CK1δ is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CK1d is activated by CCK2R and it then phosphorylates polycystin 2 (PKD2) at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CKId can phosphorylate in vitro deoxycytidine kinase (dCK), which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKId in vitro correlates with increased activity of this enzyme.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
产品性质
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 70-94 nmol/min·mg |
| 分子量 | ~72 kDa |
| NCBI登记号 | NM_001893 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... CSNK1D(1453) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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