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Cofilin 1 Active human

活性Cofilin 1 人

品牌
Sigma-Aldrich
货号
SRP0254
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
参考价格
7994.75 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Cofilin 1 Active human
Cofilin, non-muscle isoform
p18
CFL1
活性Cofilin 1 人
产品介绍:

产品说明

一般描述

Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,
Cofilin 1 is ubiquitously expressed and has a molecular mass of ~19kDa.
Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,

应用

Kinase substrate for the kinase assay; western blot

生化/生理作用

Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the gene is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, abnormal expression of the gene leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. CFL1 facilitates cytokinesis, cell motility and morphogenesis. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by Syns.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

产品性质

生物来源human
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式aqueous solution
分子量 44 kDa
包装pkg of 200 μg
浓度>0.02 mg/mL
NCBI登记号NM_005507
UniProt登记号P23528
运输dry ice
储存温度−70℃
Gene Informationhuman ... CFL1(1072)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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