Dapagliflozin propanediol monohydrate

产品名称：

960404-48-2
Dapagliflozin propanediol monohydrate
Dapagliflozin propanediol hydrate
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (S)-propane-1,2-diol (1:1) monohydrate
BMS 512148 propanediol hydrate
Dapagliflozin (S)-propylene glycol monohydrate
(2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyl-tetrahydro-2H-pyran-3,4,5-triol propanediol monohydrate
BMS-512148 propanediol hydrate

产品介绍：

产品说明

生化/生理作用

Dapagliflozin (BMS-512148) is an orally active, potent and selective renal sodium-dependent glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor (human/rat SGLT2 IC₅₀ = 1.1/3 nM vs. human/rat SGLT1 IC₅₀ = 1.39/0.6 μM; R-methyl-D-glucopyranoside (AMG) uptake assay with respective CHO transfectants). Dapagliflozin reduces blood glucose levels (by 55% in streptozotocin (STZ)-induced hyperglycemic rats 5 hrs post 0.1 mg/kg p.o.) by preventing the renal glucose reabsorption process and promoting glucose excretion in urine with good pharmacokinetic properties and oral availability (84% in rats and 83% in dogs, respectively, post 1 mg/kg and 6.6 mg/kg p.o.) in vivo.

基本信息

经验(实验)分子式	C₂₁H₂₅ClO₆·C₃H₈O₂·H₂O
分子量	502.98
MDL编号	MFCD28167768

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D 20 to 26, c = 0.2 in chloroform-d
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable