(-)-2′3′-Dideoxy-5-fluoro-3′-thiacytidine

产品名称：

143491-57-0
Emtricitabine
524W91
BW 524W91
BW524W91
BW-524W91
BW-1592
FTC
BW1592
4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
(2R,5S)-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
(-)-2′3′-Dideoxy-5-fluoro-3′-thiacytidine
5-Fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
BW 1592
(-)-FTC; (-)-2′,3′-Dideoxy-5-fluoro-3′-thiacytidine
(2R-cis)-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

产品介绍：

产品说明

生化/生理作用

Emtricitabine ((-)-FTC) is an orally active, non-cytotoxic (>100 μM/PBM, CEM, Vero, MT-4), potent nucleoside reverse transcriptase inhibitor (NRTI) against HIV type 1/2 (HIV-1 IC50/culture = 8 nM/PBM (LAV-1), 9 nM/CEM (LAV-1); HIV-2 IC50/culture = 0.7 nM/PBM (ROD2), 100 nM/CEM (Zy)), hepatitis B, as well as simian and feline immunodeficiency viruses. Emtricitabine is activated via 2′-deoxycytidine kinase-mediated phosphorylation to (-)-FTC-5′-triphosphate that inhibits viral reverse transcriptase in a dCTP-competitive manner (HIV-1 Ki = 2.9 μM).

基本信息

经验(实验)分子式	C₈H₁₀FN₃O₃S
分子量	247.25

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -150 to -125°, c = 0.25 in methanol
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
InChI	1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
InChI key	XQSPYNMVSIKCOC-NTSWFWBYSA-N