产品说明
一般描述
Etoposide-quinone is a major metabolite of anticancer drug etoposide, which may contribute to the development of secondary acute myeloid leukemias in some etoposide patients. Etoposide-quinone is a covalent poison of human topoisomerase IIb, which induces four times more topoisomerase IIb mediated DNA cleavage than etoposide. Etoposide-quinone is a potent (IC50 = 7 μM) irreversible inhibitor of TCPTP protein tyrosine phosphatase that increases STAT1 tyrosine phosphorylation and contributes to etoposide dependent leukemogenesis.
应用
Application: Metabolomics
基本信息
| 经验(实验)分子式 | C28H28O13 |
| 分子量 | 572.51 |
产品性质
| 质量水平 | 100 |
| 生物来源 | synthetic |
| 等级 | research grade |
| 测定 | ≥93% (H-NMR) |
| 形式 | solid |
| technique(s) | HPLC: suitable |
| 颜色 | dark red |
| 储存温度 | −20℃ |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H350 - H361d |
| 预防措施声明 | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Oral - Carc. 1B - Repr. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
