产品说明
生化/生理作用
Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations.
Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen.
重悬
For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer.
基本信息
| 经验(实验)分子式 | C24H21F2NO3 |
| 分子量 | 409.43 |
| MDL编号 | MFCD00937872 |
| PubChem化学物质编号 | 329825513 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 溶解性 | DMF: soluble ≥15 mg/mL DMSO: soluble ≥15 mg/mL ethanol: soluble ≥15 mg/mL methanol: soluble ≥15 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O |
| InChI | 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 |
| InChI key | OLNTVTPDXPETLC-XPWALMASSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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