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位置:首页 > 品牌 > Sigma-Aldrich > 3-[3-[(Cyclohexylcarbonyl)[[4′-(dimethylamino)[1,1′-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester

Fexaramine

3-[3-[(Cyclohexylcarbonyl)[[4′-(dimethylamino)[1,1′-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester

品牌
Sigma-Aldrich
CAS
574013-66-4
货号
SML1390
规格纯度
≥98% (HPLC)
参考价格
1399.43 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
574013-66-4
Fexaramine
3-[3-[(Cyclohexylcarbonyl)[[4′-(dimethylamino)[1,1′-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
产品介绍:

产品说明

一般描述

Fexaramine belongs to the nuclear hormone receptor family.

应用

Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model.

包装

5, 25 mg in glass bottle

生化/生理作用

Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.
Fexaramine is a potent and selective agonist of the bile acid sensor farnesoid X receptor (FXR) in the gut with an EC50 of 25 nM and no activity found for other nuclear receptors. Fexaramine induces enteric fibroblast growth factor 15 (FGF15), causing alterations in bile acid composition without activating FXR target genes in the liver. In mouse studies, fexaramine enhanced thermogenesis and browning of white adipose tissue while reducing diet-induced weight gain, body-wide inflammation and hepatic glucose production. Fexaramine also improved insulin responsiveness.

基本信息

经验(实验)分子式C32H36N2O3
分子量496.64
MDL编号MFCD09971007
PubChem化学物质编号329825838
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃
SMILES stringCN(C)C(C=C1)=CC=C1C2=CC=C(CN(C3=CC=CC(/C=C/C(OC)=O)=C3)C(C4CCCCC4)=O)C=C2
InChI1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+
InChI keyVLQTUNDJHLEFEQ-KGENOOAVSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H413
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Chronic 4
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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