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GFRA2/GDNFRB human

品牌
Sigma-Aldrich
货号
SRP6475
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
参考价格
3896.85 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
GFRA2/GDNFRB human
RETL2
NTNRA
TRNR2
NRTNR-ALPHA
产品介绍:

产品说明

一般描述

GDNF family receptor α-2 (GFRA2) also known as GDNF receptor β, Neurturin receptor α, RET ligand 2, TGF-β-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-β superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥95% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 47.6 kDa
observed mol wt 60-70 kDa (DTT-reduced. Ser 22 is the predicted N-terminal.)
包装pkg of 20 and 100 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号O00451
运输wet ice
储存温度−20℃
Gene Informationhuman ... GFRA2(2675)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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