产品说明
一般描述
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
外形
Solution in 10 mM glycine, pH 10.0.
其他说明
The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
法律信息
FLAG is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in HEK 293 cells |
| 标签 | FLAG® tagged |
| 测定 | >90% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | ~22 kDa by SDS-PAGE |
| 包装 | pkg of 50 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 浓度 | ≥0.2 mg/mL |
| 杂质 | <0.1 EU/μg endotoxin, tested |
| 颜色 | clear |
| UniProt登记号 | Q7TS55 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Tnfsf18(240873) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
Sigma-Aldrich
m.cnreagent.com
