您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Histone H3 (1-136) human

Histone H3 (1-136) human

品牌
Sigma-Aldrich
货号
SRP6586
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
3599.48 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Histone H3 (1-136) human
Histone H3/b
Histone H3/c
Histone H3/a
Histone H3/l
Histone H3/j
Histone H3/h
Histone H3/k
Histone H3/f
Histone H3/I
Histone H3/d
产品介绍:

产品说明

一般描述

The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)2. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A).

生化/生理作用

Histone proteins are basic building blocks of chromatin. Changes in the circulating H3 levels are associated with death in sepsis patients. Post-translational modifications of histone tails control chromatin organization and gene transcription. Trimethylated histone H3 lysine 4 (H3K4me3) is present at actively transcribed genes and it helps in promotion of gene expression. Histone H3K36 trimethylation (H3K36me3) is lost in various cancers and is linked with poor patient outcome. Dimethylated H3K9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells.

外形

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥95% (SDS-PAGE)
形式lyophilized powder
分子量 15.5 kDa (1-136 aa)
包装pkg of 100 and 250 μg
UniProt登记号P68431
运输dry ice
储存温度−70℃
Gene Informationhuman ... HIST1H3A(8350)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品