产品说明
一般描述
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
外形
Lyophilized from PBS and 0.5% trehalose.
重悬
Reconstitute with 100 μL deionized water.
其他说明
IL-36gamma (mouse) (aa 13-164) is untagged.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in E. coli |
| 偶联物 | untagged |
| 测定 | >95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | ~17 kDa |
| 包装 | pkg of 10 μg |
| 杂质 | <0.01 EU/μg endotoxin, tested |
| 颜色 | white |
| UniProt登记号 | Q8R460 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Il36g(215257) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
