产品说明
一般描述
Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
序列
Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.
外形
Lyophilized. Contains PBS + 0.02 % CHAPS.
重悬
Reconstitute with 100μl sterile water.
基本信息
| NACRES | NA.32 |
产品性质
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | ~150 kDa by SDS-PAGE |
| 杂质 | <0.1 EU/μgtested |
| UniProt登记号 | Q9Y219 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... JAG2(3714) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
