产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.
基本信息
| 经验(实验)分子式 | C26H22F6O2 |
| 分子量 | 480.44 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 15 mg/mL, clear |
| 创始人 | Johnson & Johnson |
| 相关疾病 | Alzheimer′s disease |
| 储存温度 | 2-8℃ |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H300 - H413 |
| 预防措施声明 | P264 - P270 - P273 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 2 Oral - Aquatic Chronic 4 |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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