JP4-039

产品名称：

1205492-16-5
JP4-039
4-[[(3E,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-7-methyl-1-oxo-3-octen-1-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy
JP 4-039

产品介绍：

产品说明

生化/生理作用

JP4-039 is an electron-/reactive oxygen species (ROS)-scavenging GS-nitroxide composed of 4-amino-TEMPO and a truncated gramicidin S (GS) mitochrondria-targeting sequence. JP4-039 is a superior irradiation mitigator than XJB-5-131 (33% vs. 20% mice survial rate on day 35 with respective compound; 23.6 μmol/kg iv. 24 hr post 9.5 Gy whole body irradiation), while displaying weaker anti-ferroptotic potency (EC₅₀ = 3.58 μM/1.27 μM against 10 μM erastin-/2 μM RSL3-induced HT-1080 ferroptosis vs. 114 nM/68 nM with XJB-5-131) due to lower lipophilicity & mitochondria enrichment. Typical dosing range: 40 nM-10 μM in cultures and 10-20 mg/kg in mice (im., ip., iv.) in vivo.

基本信息

经验(实验)分子式	C₂₃H₄₂N₃O₄
分子量	424.60

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faint yellow to dark orange
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O=C(C/C=C/[C@@H](NC(OC(C)(C)C)=O)CC(C)C)NC1CC(C)(C)N([O])C(C)(C)C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3