产品说明
一般描述
LAG3 (lymphocyte activation gene 3), first identified in activated natural killer cells (NK cells), is a transmembrane protein belonging to the Ig (immunoglobulin) superfamily. It is composed of four extracellular Ig-like domains, and the outermost domain has an unusual loop-like insertion. This cell is expressed in activated NK and T cells.
生化/生理作用
Studies in mice with null mutation for LAG3 (lymphocyte activation gene 3) gene show that this protein is involved in pathways involving natural killer (NK) cells, as in these mice, NK cells are incapable of killing certain tumor targets. This protein is expressed by activated CD4+ T cells, which results in the production of IFN-γ (interferon). This protein is thought to interact with MHC II (major histocompatibility class) molecules on immature DCs (dendritic cells), thus activating and maturing APCs (antigen presenting cells).
外形
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重悬
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 标签 | 6-His tagged (C-terminus) |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | calculated mol wt 47 kDa observed mol wt 60 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 23 is the predicted N-terminus.) |
| 包装 | pkg of 10 and 50 μg |
| UniProt登记号 | P18627 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... LAG3(3902) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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