Leukadherin-1

产品名称：

344897-95-6
Leukadherin-1
4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid
Leukadherin 1
Leukadhedrin 1
LA1

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.
Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

基本信息

经验(实验)分子式	C₂₂H₁₅NO₄S₂
分子量	421.49
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, yellow to orange to brown
溶解性	DMSO: 3 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable