LOXL2 human

产品名称：

LOXL2 human
LOR2
WS9-14
lysyl oxidase-like 2

产品介绍：

产品说明

一般描述

Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.

生化/生理作用

Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.

外形

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

法律信息

FreeStyle is a trademark of Invitrogen Corp.

基本信息

NACRES

NA.32

产品性质

生物来源	human
重组	expressed in FreeStyle^™ 293-F cells
测定	≥86% (SDS-PAGE)
形式	aqueous solution
分子量	85 kDa
包装	pkg of 10 μg
储存条件	avoid repeated freeze/thaw cycles
浓度	0.23 mg/mL
NCBI登记号	NM_002318
UniProt登记号	Q9Y4K0
运输	dry ice
储存温度	−70℃
Gene Information	human ... LOXL2(4017)

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H319 - H360D
预防措施声明	P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类	Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable