产品说明
一般描述
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
生化/生理作用
Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.
外形
Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.
法律信息
FreeStyle is a trademark of Invitrogen Corp.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in FreeStyle™ 293-F cells |
| 测定 | ≥86% (SDS-PAGE) |
| 形式 | aqueous solution |
| 分子量 | 85 kDa |
| 包装 | pkg of 10 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 浓度 | 0.23 mg/mL |
| NCBI登记号 | NM_002318 |
| UniProt登记号 | Q9Y4K0 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... LOXL2(4017) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H315 - H319 - H360D |
| 预防措施声明 | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| 危险分类 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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