4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one 4-methylbenzenesulfonate

品牌

Sigma-Aldrich

CAS

1187020-80-9

货号

SML2866

包装型号

规格纯度

≥98% (HPLC)

参考价格

940.27 元 *本价格含增值税费

促销

数量

产品名称：

1187020-80-9
Lumateperone tosylate
ITI-007
4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one 4-methylbenzenesulfonate
1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]butan-1-one 4-methylbenzenesulfonate

产品介绍：

产品说明

生化/生理作用

Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (K_i = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID₅₀ = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID₅₀ = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.

基本信息

经验(实验)分子式	C₂₄H₂₈FN₃O · C₇H₈O₃S
分子量	565.70
MDL编号	MFCD29922434

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -10 to -14, c = 1 in DMSO
颜色	white to very dark gray
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC=C(F)C=C1)CCCN2CC[C@]([C@@]3([H])C2)([H])N4CCN(C)C5=C4C3=CC=C5.O=S(C6=CC=C(C)C=C6)(O)=O

安全信息

象形图
警示用语：	Warning
危险声明	H336 - H361f
预防措施声明	P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
危险分类	Repr. 2 - STOT SE 3
靶器官	Central nervous system
储存分类代码	11 - Combustible Solids
WGK	WGK 3