5-Methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid

产品名称：

220991-20-8
Lumiracoxib
COX-189
COX189
5-Methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid
LMX
CGS-35189
CGS 35189
CGS35189
2-[(2-Chloro-6-fluorophenyl)amino]-5-methyl-benzeneacetic acid
COX 189
Non-steroidal anti-inflammatory drug

产品介绍：

产品说明

生化/生理作用

Lumiracoxib (COX189) is an orally active, potent and selective cyclooxygenase-2 inhibitor (K_i = 60 nM/COX-2 vs. 3.2 μM/COX-1) that inhibits COX-2-mediated PGE2 production in human whole blood (IC₅₀ = 130 nM; stimulation = 50 μM A23187), but not COX-1-dependent TxB2 production (IC₅₀ = 67 μM; stimulation = 10 μg/mL LPS). Lumiracoxib shows in vivo anti-inflammatory efficacy against carrageenan-induced paw oedema (ED₃₀ = 0.35 mg/kg p.o.), CFA-induced hyperalgesia (ED₃₀ = 5.1 mg/kg p.o.), as well as adjuvant-induced arthritis (ED₅₀ = 3 mg/kg/day p.o.) in rats in vivo.

基本信息

经验(实验)分子式	C₁₅H₁₃ClFNO₂
分子量	293.72
MDL编号	MFCD07186254

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC1=CC=CC(F)=C1NC2=CC=C(C)C=C2CC(O)=O

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable