产品说明
特点和优势
m-dPEG37-NHS ester is a methyl-terminated, single molecular weight, discrete chain length polyethylene glycol (dPEG) spacer. The carboxylic acid moiety on the end of the molecule opposite the methyl cap is activated with N-hydroxysuccinimide (NHS) for facile reaction with free amines. The dPEG spacer is 112 atoms (133.9 Å) long, a monodisperse equivalent of a polymeric PEG1500. m-dPEG37-NHS ester can be used to modify silica shelled quantum dots to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Overall, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, and improved PK and BD properties.
法律信息
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
基本信息
经验(实验)分子式 | C80H155NO41 |
分子量 | 1787.07 |
MDL编号 | MFCD21363217 |
产品性质
测定 | >95% (HPLC) |
形式 | solid or viscous liquid |
reaction suitability | reaction type: Pegylations |
聚合物结构设计 | shape: linear functionality: monofunctional |
运输 | ambient |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich