产品说明
一般描述
MEKK6 or MAP3K6 (mitogen-activated protein kinase kinase kinase 6) is a member of the serine/threonine protein kinase family. MEKK6 was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. MEKK6 cascades relay signals from the cell surface to the nucleus which result in gene transcription. MEKK6 activates the JNK and p38 pathway and induces apoptosis when overexpressed in stably transfected cells. MEKK6 transcript is expressed in several tissues, with the highest expression in heart and skeletal muscle.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
制备说明
After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 8-12 nmol/min·mg |
| 分子量 | ~67 kDa |
| NCBI登记号 | NM_004672 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... MAP3K6(9064) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
