产品说明
一般描述
CD38 is a 45 kDa type II integral membrane glycoprotein consisting of an N-terminal 20 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 257 amino acid extracellular domain. CD38 is associated with different molecules in different cell types and these unique combinations cause unique cell-type specific signaling. One of the known ligands that activates CD38-mediated signaling is CD31 (Deaglio, 2001). CD38 is expressed by a number of different cell types and the pattern of expression often changes with differentiation and maturation. Thus, CD38 expression is found during early stages of B and T-cell differentiation, is lacking during the later intermediate stages, and is regained near the end of maturation. CD38 is expressed at variable levels on the majority of hematopoietic cells, prevalently during early differentiation and activation, and it is expressed strongly on plasma cells (Jackson, 1990; Terstappen, 1990; Morra, 1997). CD38-postive cell types outside the hematopoietic system include subsets from the gut, brain, prostate, pancreas, bone, eye, and muscle (Deaglio, 2001). CD38 is expressed on approximately 60% of CD34-positive peripheral blood mononuclear cells. The least mature CD34-postive cells are characterized by a lack of CD38 (Herbein, 1994).
Anti-CD38, AT13/5 was included in the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD38 (Morra, 1997).
特异性
Antibody recognizes Human CD38 antigen.
免疫原
Namalwa cells (B lymphocyte cell line from Burkitt′s lymphoma)
应用
Research Sub Category
Immunoglobulins & Immunology
Milli-Mark Anti-CD38-FITC Antibody, clone AT13/5 is an antibody against CD38 for use in FC.
Research Category
Inflammation & Immunology
质量
Evaluated by flow cytometry using human lymphocytes
目标描述
45 kDa (Deaglio, 2001)
外形
Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Protein A purified
储存及稳定性
Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
分析说明
Control
Human Lymphocytes
法律信息
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.44 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
偶联物 | FITC conjugate |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | AT13/5, monoclonal |
species reactivity | human |
manufacturer/tradename | Milli-Mark® |
technique(s) | flow cytometry: suitable |
同位素/亚型 | IgG1κ |
NCBI登记号 | NP_001766 |
UniProt登记号 | P28907 |
运输 | wet ice |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich