ML239

产品名称：

1378872-36-6
ML239
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide

产品介绍：

产品说明

应用

ML239 has been used as a proble in cellular lipid profiling.

包装

5, 25 mg in glass bottle

生化/生理作用

ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.
ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line.

基本信息

经验(实验)分子式	C₁₃H₁₀Cl₃N₃O₂
分子量	346.60
MDL编号	MFCD23098913
PubChem化学物质编号	329824724
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL (clear solution)
储存温度	2-8℃
SMILES string	Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
InChI	1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
InChI key	NVEDPFICKAIHKD-NGYBGAFCSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H400
预防措施声明	P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable