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Monoclonal Anti-ALIX/PDCD6IP antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200646
规格纯度
clone ALIX-1, purified from hybridoma cell culture
参考价格
6092.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-ALIX/PDCD6IP antibody produced in mouse
产品介绍:

产品说明

一般描述

Anti-ALIX/PDCD6IP antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma ALIX-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal region of human ALIX/ PDCD6IP, conjugated to KLH. ALIX (Apoptosis-linked gene 2 (ALG-2)-interacting protein X), also named Programmed Cell Death 6 interacting protein (PDCD6IP).

免疫原

peptide corresponding to an internal region of human ALIX/ PDCD6IP

应用

Monoclonal Anti-ALIX/PDCD6IP antibody has been used in

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence
  • flow cytometry

生化/生理作用

ALIX (Apoptosis-linked gene 2 (ALG-2)-interacting protein X) plays a role in ESCRT (endosomal sorting complexes required for transport) pathway. It is involved in the abscission stage of cytokinesis, in intralumenal endosomal localization, and in enveloped virus budding. Overexpression of this protein can block apoptosis. In addition, ALIX binds to PDCD6, a protein required for apoptosis, in a calcium-dependent manner. ALIX also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of ALIX and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆ALIX-1, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度~1 mg/mL
technique(s)flow cytometry: 5-10 μg/test using using human MOLT4 cells
immunoblotting: 2-5 μg/mL using using whole extracts of human MOLT4 cells.
immunofluorescence: 10-20 μg/mL using using human HeLa cells
immunoprecipitation (IP): 10-20 μg/mL using using lysates of human MOLT4 cells.
同位素/亚型IgG1
UniProt登记号Q8WUM4
运输dry ice
储存温度−20℃
Gene Informationhuman ... PDCD6IP(10015)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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