Monoclonal Anti-CD16-PE antibody produced in mouse

产品说明

一般描述

Cluster of differentiation 16 (CD16), also known as Fc fragment of IgG receptor IIIa (FCGR3A) gene, is localized to human chromosome 1 and codes for FC γ IIIa receptor (FcγRIIIa). The encoded protein is expressed on natural killer (NK) cells and macrophages. CD16 is a transmembrane protein characterized with a 21 amino acid cytoplasmic tail.
The antibody MEM-154 reacts with the epitope on CD16 antigen that residing in proximity to FG loop (probably BC or C′E loop). CD16 is a low affinity receptor for aggregated IgG (FcgammaRIII antigen). The antibody MEM-154 reacts with CD16+ granulocytes.

免疫原

Human granulocytes

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

生化/生理作用

Cluster of differentiation 16 (CD16) is one of the activating Fc receptors to which, the Fc region of immunoglobulin G (IgG) binds and mediates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC). Dimorphism in CD16 might influence the therapeutic response to rituximab, which is an anti-CD20 humanized immunoglobulin G1 extensively used in the treatment of non-hodgkin lymphomas. Mutation in the gene might lead to natural killer (NK) cell immunodeficiency.

特点和优势

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外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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