Monoclonal Anti-CD90.2, azide free antibody produced in mouse

产品说明

一般描述

Cluster of differentiation 90.2 (CD90.2), also known as Thy-1.2, is a 25-37kDa GPI-anchored protein, encoded by the gene mapped to mouse chromosome 9. The protein is mainly localized on the external leaflet of the lipid bilayer and lipid rafts. The encoded protein is one of the allele of CD90 and is expressed primarily on murine T-cells.
The mouse monoclonal antibody 1aG4/C5 recognizes alloantigen Thy-1.2 of mouse Thy-1 (CD90); it does not cross-react with Thy-1.1 alloantigen. Thy-1 is an 18-35 kDa cell surface GPI linked glycoprotein (immunoglobulin superfamily); in mouse it is abundant on thymocytes and peripheral T lymphocytes.

免疫原

thymocytes from C3H/Di mice (Thy-12 positive)

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation 90.2 (CD90.2) plays a major role in T-cell activation. In addition, it is also implicated in various nonimmunologic functions such as, inhibition of neurite outgrowth, apoptotic signaling, leukocyte and melanoma cell adhesion and migration, tumor suppression and fibroblast proliferation and migration. CD90. also acts as a tumor suppressor in ovarian cancer and nasopharyngeal carcinoma (NPC). Deficiency of CD90 is associated with the development of pulmonary fibrosis. The protein expressed in choroidal endothelial cells (CECs) modulates VEGF-mediated CEC activation and migration.

特点和优势

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外形

Solution in azide free HEPES buffer, pH 7

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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