Monoclonal Anti-Esrp-1/2 antibody produced in mouse

产品说明

一般描述

Epithelial splicing regulatory protein 1 (ESRP1) is a member of RBM family of RNA-binding proteins. It is also known as RBM35A. ESRP1 get highly expressed in both mouse and human epithelial stem cells and weakly expressed in normal pancreatic ductal cells.

特异性

This antibody was purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with both mouse Esrp-1 and Esrp-2 proteins.  A BLAST analysis of the immunizing protein sequence shows 100% homology with Esrp-1 from mouse and a 91% sequence homology with Esrp-1 from human, pig, rat, opossum, horse, cattle, panda, dog, and chimpanzee .  The binding epitope of this monoclonal antibody has not been mapped

免疫原

Full length recombinant mouse Esrp-1 fusion protein.

生化/生理作用

Epithelial splicing regulatory protein 1 (ESRP1) is essential for the expression of epithelial FGFR2-IIIb (fibroblast growth factor receptor 2). Suppression of ESRP1 can enhance induced pluripotent stem (iPS) cell colony generation. It can also repress cancer cell motility by different mechanisms. ESRP1 modulates splicing of Ras-related C3 botulinum toxin substrate 1 (Rac1) isoforms and participates in the maintenance of epithelial cell-specific isoforms. The protein controls epithelial splicing regulatory network and pluripotency.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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