产品说明
一般描述
Frizzled class receptor 7 (FZD7) is an oncogene involved in various malignancies. It is a receptor of Wingless (WNT) proteins. The protein possesses seven hydrophobic domains. The gene encoding FZD7 is localized on human chromosome 2q33.1.
免疫原
FZD7 (NP_003498.1, 155 a.a. ~ 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
生化/生理作用
Frizzled class receptor 7 (FZD7) modulates sensitivity to chemotherapeutic drugs. It functions in tumor initiation in melanoma cells. The protein acts as a mediator in canonical and non-canonical Wnt signaling pathways.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD06798447 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 4D9, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~37 kDa |
| species reactivity | human |
| technique(s) | ELISA: suitable capture ELISA: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NM_003507 |
| UniProt登记号 | O75084 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... FZD7(8324) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
