产品说明
一般描述
Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC are present in changeable volumes on all nucleated cells.
The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.
免疫原
Leukocytes of a patient suffering with LGL type leukemia
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
基本信息
NACRES | NA.41 |
产品性质
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | MEM-81, monoclonal |
形式 | buffered aqueous solution |
species reactivity | human |
浓度 | 1 mg/mL |
technique(s) | flow cytometry: suitable |
同位素/亚型 | IgG1 |
NCBI登记号 | NM_002116.6 NM_002117.4 NM_005514.6 |
UniProt登记号 | P01891 |
运输 | wet ice |
储存温度 | 2-8℃ |
Gene Information | human ... HLA-A(3105), HLA-B(3106), HLA-C(3107) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich